Immunosuppressive Functions of Core2 <i>O</i>-Glycans against NK Immunity

DOI Web Site 44 References
  • Tsuboi Shigeru
    Department of Cancer Immunology and Cell Biology, Oyokyo Kidney Research Institute Department of Urology, Hirosaki University Graduate School of Medicine

Bibliographic Information

Other Title
  • NK免疫に対するコア2<i>O</i>-グリカンの免疫抑制機能
  • Immunosuppressive Functions of Core2 O-Glycans against NK Immunity

Search this article

Abstract

The O-glycan branching enzyme, core2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) forms O-glycans containing a branch of β-1,6-linkage of N-acetylglucosamine and N-acetylgalctosamine (core2 O-glycans) on cell-surface glycoproteins. It was reported that expression of C2GnT, a key enzyme for core2 O-glycans expression, was closely correlated with high-metastatic phenotypes of numbers of cancers. Recently, it has been revealed that C2GnT-expressing cancer cells synthesize core2 O-glycans which have immunosuppressive functions against natural killer (NK) cell immunity by using their cell-surface core2 O-glycans, resulting in acquiring high-metastatic phenotypes. C2GnT-expressing cancer cells have two different types of immunosuppressive functions against NK cell immunity, molecular shield and tumor-ligand masking. Here, we highlight recent advances in our understanding of the detailed molecular mechanisms of those immunosuppressive functions of core2 O-glycans.

Journal

References(44)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top