Angiopoietion-Like Protein 2 Is Associated With Chronic Kidney Disease in a General Japanese Popolation : The Hisayama Study

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Author(s)

    • USUI Tomoko
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University
    • NINOMIYA Toshiharu
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University
    • NAGATA Masaharu
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University
    • TAKAHASHI Otowa
    • Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
    • DOI Yasufumi
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University
    • HATA Jun
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University
    • FUKUHARA Masayo
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University
    • KITAZONO Takanari
    • Department of Medicine and Clinical Science Graduate School of Medical Sciences, kyushu University
    • OIKE Yuichi
    • Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
    • KIYOHARA Yutaka
    • Department of Environmental Medicine Graduate School of Medical Sciences, Kyushu University

Abstract

<b><i>Background:</i></b> Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). <b><i>Methods and Results:</i></b> A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0mg/g) or decreased estimated glomerular filtration rate (eGFR <60ml·min<sup>–1</sup>·1.73m<sup>–2</sup>). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01ng/ml: OR, 1.00 (reference); 2.01–2.48ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24–2.24; 2.49–2.99ng/ml: OR, 1.70, 95% CI: 1.27–2.28; 3.00–3.65ng/ml: OR, 1.78, 95% CI: 1.32–2.39; ≥3.66ng/ml: OR, 1.79, 95% CI: 1.32–2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). <b><i>Conclusions:</i></b> Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.  (<i>Circ J</i> 2013; <b>77:</b> 2311–2317)<br>

Journal

  • Circulation Journal

    Circulation Journal 77(9), 2311-2317, 2013-08-25

    The Japanese Circulation Society

References:  31

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