Pancreatic beta cell function in lean and obese Japanese with various degrees of glucose tolerance

• Takahara Mitsuyoshi

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan

• Katakami Naoto

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan

• Kaneto Hideaki

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan

• Noguchi Midori

  Health Support Promotion Section, Environment and Civic Affairs Bureau, Amagasaki City Office, Amagasaki 660-0051, Japan

• Shimomura Iichiro

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan

抄録

The aim of the current study was to investigate whether obese subjects have different insulin secretory capacity compared to lean subjects with the same glucose tolerance in a Japanese population. We included a total of 1749 Japanese employees who underwent 75-g oral glucose tolerance test (OGTT). The study population was divided into deciles of 120-min glucose levels and the indices of insulin secretion and insulin sensitivity in each decile were compared between the subjects with and without obesity (body mass index ≥ 25 kg/m²). The indices used in the current study were Matsuda index, insulinogenic index, and disposition index. Obese subjects had significantly lower values of Matsuda index and significantly higher value of insulinogenic index than non-obese subjects in every decile (all p < 0.05). On the other hand, disposition index was not significantly different between non-obese and obese subjects in any decile of 120-min glucose level (all p > 0.05). Similar findings were observed when the study population was classified by waist circumference. In conclusion, disposition index derived from the data of 75-g OGTT was similarly decreased in obese Japanese subjects compared to non-obese Japanese subjects with the same post-load glucose levels. Future studies will be needed to confirm whether the development of glucose intolerance in obese Japanese subjects is accompanied by the same degree of pancreatic beta cell dysfunction as non-obese Japanese subjects.

収録刊行物

• Endocrine Journal

  Endocrine Journal 60 (7), 923-930, 2013

  一般社団法人 日本内分泌学会

キーワード

• Obesity
• Japanese
• Beta cell function

詳細情報

• CRID: 1390282681273978752
• NII論文ID: 10031195761
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.ej13-0046
• COI: 1:STN:280:DC%2BC3svms12itQ%3D%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 23503328
• Web Site: https://www.jstage.jst.go.jp/article/endocrj/60/7/60_EJ13-0046/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014181357
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可