Fermentative Production of Plant Benzylisoquinoline Alkaloids in Microbes

• MINAMI Hiromichi

  Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University

Bibliographic Information

Other Title

• Award Review : Fermentative Production of Plant Benzylisoquinoline Alkaloids in Microbes

Abstract

Higher plants produce diverse chemicals, including alkaloids, terpenoids, and phenolic compounds (phenylpropanoids and flavonoids) as secondary metabolites. These chemicals are widely used for human health and nutrition. Alkaloids, for example, are valued in medicine due to their high biological activities, but most of these metabolites accumulate at low levels in plant cells, resulting in poor extraction yields. Increasingly, attention is devoted to the production of plant metabolites by reconstructing plant biosynthetic pathways in microorganisms. This technology has been aided by advances in synthetic biology and metabolic engineering. Here, the review a fermentation platform for low-cost production of numerous alkaloids using bioengineered Escherichia coli and/or Saccharomyces cerevisiae.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 77 (8), 1617-1622, 2013

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• benzylisoquinoline alkaloid
• reticuline
• fermentative production
• synthetic biology
• metabolic engineering

Details

• CRID: 1390282681455401216
• NII Article ID: 10031195806
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.130106
• COI: 1:STN:280:DC%2BC3sfns1Ontg%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 024791533
• PubMed: 23924710
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024791533
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.130106
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed