Role of Nuclear Localization of PSMB1 in Transcriptional Activation

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  • YAMAUCHI Jun
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • SEKIGUCHI Mariko
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • SHIRAI Tomomi
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • YAMADA Mami
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • ISHIMI Yoshiko
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

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The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.

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