New Treatment Strategies to Eradicate Cancer Stem Cells and Niches in Glioblastoma

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Author(s)

    • HIDE Takuichiro
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • MAKINO Keishi
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • NAKAMURA Hideo
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • YANO Shigetoshi
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • ANAI Shigeo
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • TAKEZAKI Tatsuya
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • KURODA Jun-ichro
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • SHINOJIMA Naoki
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • UEDA Yutaka
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science
    • KURATSU Jun-ichi
    • Department of Neurosurgery,Kumamoto University Graduate School of Medical Science

Abstract

Glioblastoma multiforme (GBM) harbors are not only rapidly dividing cells but also small populations of slowly dividing and dormant cells with tumorigenesity, self-renewal, and multi-lineage differentiation capabilities. Known as glioblastoma stem cells (GSCs), they are resistant to conventional chemo- and radiotherapy and may be a causative factor in recurrence. The treatment outcome in patients with GBM remains unsatisfactory and their mean survival time has not improved sufficiently. We studied clinical evidence and basic research findings to assess the possibility of new treatment strategies that target GSCs and their specific microenvironments (GBM niches) and raise the possibility of adding new treatments to eradicate GSCs and GBM niches.

Journal

  • Neurologia medico-chirurgica

    Neurologia medico-chirurgica 53(11), 764-772, 2013-11-15

    The Japan Neurosurgical Society

References:  84

Codes

  • NII Article ID (NAID)
    10031196787
  • NII NACSIS-CAT ID (NCID)
    AN00358613
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    04708105
  • Data Source
    CJP  J-STAGE 
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