Role of NRSF/REST in the Regulation of Cardiac Gene Expression and Function

• Kuwahara Koichiro

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

抄録

Alterations in the cardiac gene program affect both cardiac structure and function, and play a key role in the progression of pathological cardiac remodeling and heart failure. For instance, reactivation of fetal cardiac genes in adults is a consistent feature of cardiac hypertrophy and heart failure. Investigation of the transcriptional regulation of cardiac genes revealed a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also called repressor element-1 silencing factor (REST), to be an important regulator of multiple fetal cardiac genes. Inhibition of NRSF in the heart leads to cardiac dysfunction and sudden arrhythmic death accompanied by re-expression of various fetal genes, including those encoding fetal ion channels, such as the HCN channels and T-type Ca²⁺ channels. These findings shed light on the crucial regulatory function of NRSF in the heart and its importance for maintaining normal cardiac integrity.  (Circ J 2013; 77: 2682–2686)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 77 (11), 2682-2686, 2013

  一般社団法人 日本循環器学会

キーワード

• Atrial natriuretic factor
• Brain natriuretic peptide
• Heart failure
• Remodeling

詳細情報

• CRID: 1390282680083058048
• NII論文ID: 10031196813
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-13-1210
• COI: 1:CAS:528:DC%2BC3sXhvVamtL%2FL
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 24126098
• Web Site: https://www.jstage.jst.go.jp/article/circj/77/11/77_CJ-13-1210/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014247684
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可