A case of calcineurin-inhibitor induced pain syndrome associated with tacrolimus therapy for ulcerative colitis

• TADANO Toshihiro

  Department of Gastroenterology, Sendai Medical Center Department of Gastroenterology, Tohoku University

• TAKAHASHI Hiroki

  Department of Gastroenterology, Sendai Medical Center

• SUGAWARA Kaori

  Department of Gastroenterology, Sendai Medical Center

• SUGIMURA Mikako

  Department of Gastroenterology, Sendai Medical Center

• IWABUCHI Masahiro

  Department of Gastroenterology, Sendai Medical Center

• MANO Yutaka

  Department of Gastroenterology, Sendai Medical Center

• UKAI Katsuaki

  Department of Gastroenterology, Sendai Medical Center

• TADOKORO Keiichi

  Department of Gastroenterology, Sendai Medical Center

• MORI Yoshimasa

  Mori Shokaki Naika Geka

Bibliographic Information

Other Title

• 潰瘍性大腸炎治療中にcalcineurin-inhibitor induced pain syndrome（CIPS）を合併した1例

Abstract

A 23-year-old woman was admitted with a relapse of ulcerative colitis. Tacrolimus therapy was initiated following inadequate response to corticosteroid therapy. Although the symptoms partially improved, she suddenly developed severe pain localized to the lower limbs on day 16 of tacrolimus therapy. By day 17, she was unable to move. Magnetic resonance imaging revealed born marrow edema in the lower limbs. We suspected calcineurin-inhibitor induced pain syndrome (CIPS) due to tacrolimus therapy. The pain improved within approximately four weeks of tacrolimus cessation. CIPS that is not associated with organ transplantation is a rare occurrence. Here we report a rare case of CIPS that was caused by tacrolimus therapy in a patient with ulcerative colitis.<br>

Journal

• Nippon Shokakibyo Gakkai Zasshi

  Nippon Shokakibyo Gakkai Zasshi 110 (10), 1783-1789, 2013

  The Japanese Society of Gastroenterology

Keywords

• 潰瘍性大腸炎
• calcineurin-inhibitor induced pain syndrome（CIPS）
• タクロリムス

Details

• CRID: 1390282681380496768
• NII Article ID: 10031201988
• NII Book ID: AN00192124
• DOI: 10.11405/nisshoshi.110.1783
• COI: 1:STN:280:DC%2BC2c%2FmtFeksQ%3D%3D
• ISSN: 13497693
• ISSN: 04466586
• PubMed: 24097149
• Web Site: https://search.jamas.or.jp/link/ui/2014024998
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed