ZnT亜鉛トランスポーターの早期分泌経路における役割

• 神戸 大朋

  京都大学大学院生命科学研究科

書誌事項

タイトル別名

• Functions of ZnT transporters localized to the early secretory pathway
• ZnT アエン トランスポーター ノ ソウキ ブンピ ケイロ ニ オケル ヤクワリ

抄録

Secretory and membrane-bound zinc enzymes have multiple important physiological functions. Hence, the activation process of these enzymes is thought to require spatially and temporally well-organized steps of zinc transport, trafficking, transfer, and coordination. However, the molecular mechanisms involved in this activation remain largely unexplored when compared with those of other metal enzymes. Further investigation is essential to understanding how zinc metabolism is sophisticatedly controlled, thereby contributing to greater understanding of zinc-related biology in contexts from physiology to diseases. In this review, current knowledge on the crucial roles of the ZnT family of zinc transporters, which are localized to the early secretory pathway, is briefly reviewed from the perspective of these transporters' involvement in the activation process of secretory and membrane-bound zinc enzymes. The roles of those ZnT transporters in the maintenance of secretory pathway homeostasis are also reviewed, emphasizing the molecular aspects.

収録刊行物

• Biomedical Research on Trace Elements

  Biomedical Research on Trace Elements 24 (3), 110-116, 2013

  日本微量元素学会

キーワード

• 早期分泌経路
• ZnT
• 亜鉛トランスポーター
• 亜鉛要求性酵素
• TNAP
• 小胞体ストレス
• 恒常性維持

詳細情報

• CRID: 1390001204367715072
• NII論文ID: 10031202789
• NII書誌ID: AN10423256
• DOI: 10.11299/brte.24.110
• ISSN: 18801404
• ISSN: 0916717X
• NDL書誌ID: 024945017
• Web Site: http://id.ndl.go.jp/bib/024945017
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024945017
• Web Site: https://search.jamas.or.jp/link/ui/2014215974
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可