<b>Difference in Ritodrine Pharmacokinetics between Singleton and Twin Pregnancies</b>
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- SOMA Mayuko
- Department of Pharmacy, Tenshi Hospital
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- KONDA Ainari
- Hokkaido Pharmaceutical University School of Pharmacy
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- FUJIEDA Satoko
- Department of Obstetrics and Gynecology, Tenshi Hospital
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- SASAKI Yoichi
- Department of Pharmacy, Tenshi Hospital
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- WATARI Michiko
- Department of Obstetrics and Gynecology, Tenshi Hospital
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- KEIRA Mitsuaki
- Department of Obstetrics and Gynecology, Tenshi Hospital
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- YOSHIDA Hiroshi
- Department of Obstetrics and Gynecology, Tenshi Hospital
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- TODA Takaki
- Hokkaido Pharmaceutical University School of Pharmacy
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- HAYAKAWA Toru
- Hokkaido Pharmaceutical University School of Pharmacy
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- KISHIMOTO Shuichi
- Laboratory of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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- FUKUSHIMA Shoji
- Laboratory of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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- INOTSUME Nobuo
- Hokkaido Pharmaceutical University School of Pharmacy
Bibliographic Information
- Other Title
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- Difference in Ritodrine Pharmacokinetics between Singleton and Twin Pregnancies
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Abstract
Aim: To determine the pharmacokinetics of ritodrine in singleton and twin pregnancies.<br>Methods: We treated 105 pregnant women (with singletons, n=67; with twins, n=38) with continuous infusion of ritodrine and then measured steady-state serum ritodrine concentrations using HPLC.<br>Results: Ritodrine clearance (mean ± SD) was significantly lower in women who delivered twins than in those who delivered singletons (1.59 ± 0.30 vs. 1.75 ± 0.43 L/h/kg; p<0.001). Serum ritodrine concentration did not differ significantly between women who delivered preterm singletons and those who delivered preterm twins (97.5 ± 61.1 vs. 89.6 ± 50.4 ng/mL; p=NS), but was significantly higher in women who delivered twins at term than in those who delivered singletons at term (85.8 ± 39.7 vs. 65.7 ± 38.7 ng/mL; p<0.001).<br>Conclusion: Ritodrine clearance was lower in twin pregnancies than in singleton pregnancies. The dose of ritodrine administered to maintain pregnancy should be controlled taking into account singleton or twin pregnancy.<br>(Jpn J Clin Pharmacol Ther 2013; 44(5): 389-394)
Journal
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- Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 44 (5), 389-394, 2013
The Japanese Society of Clinical Pharmacology and Therapeutics
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Details 詳細情報について
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- CRID
- 1390282680343671680
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- NII Article ID
- 130004541551
- 10031203187
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- NII Book ID
- AN0025404X
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- COI
- 1:CAS:528:DC%2BC2cXitVeju7Y%3D
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- ISSN
- 18828272
- 03881601
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed