A Flow-Microreactor Approach to Organolithium Reactions

• Nagaki Aiichiro

  Graduate School of Engineering, Kyoto University

Bibliographic Information

Other Title

• マイクロリアクターによる有機リチウム化学の新展開
• マイクロリアクター ニ ヨル ユウキ リチウム カガク ノ シン テンカイ

Abstract

Chemical synthesis in microreactors has received significant research interests both from academia and industry. Herein we report that organolithium reactions that are difficult to be done in batch can be achieved in flow microreactors. Characteristic features of flow microreactors such as precise residence time control are responsible for the control of unstable organolithiums. Protecting-group free synthesis and stereoselective synthesis using unstable organolithiums using flow microreactors serve as powerful tools in organic synthesis. Integration of such organolithium reactions also enhances the power and speed of organic synthesis and polymer synthesis.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 71 (10), 1002-1019, 2013

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• flow microreactor
• fast mixing
• precise residence time control
• precise temperature control
• halogen-lithium exchange reaction
• protecting-group free synthesis
• stereoselective synthesis
• anionic polymerization
• reaction integration

Details

• CRID: 1390282680316917504
• NII Article ID: 10031203353
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.71.1002
• COI: 1:CAS:528:DC%2BC3sXhs1Oiu7vP
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 024935086
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024935086
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed