Effects of Cyclophosphamide on Lymph Nodes and Pyroninophilic Cells

• Jidoi, Joji

• Yamasaki, Masahiro

• Takagaki, Kenji

• Yamamoto, Shoso

• Motizuki, Teruso

• Inada, Shuichi

抄録

Cyclophosphamide was given intraperitoneally to guinea pigs in a dose of 10 mg/day for a period of 5 days and the histological changes were studied on the 1st,5th and 10th days after the administration. Changes in number of pyroninophilic cells due to DNCB sensitization were also studied. On the 1st day after discontinuation of Cyclophosphamide, the germinal centres, lymph follicles and paracortical areas of the lymph nodes all showed the same degree of cell component loss, but on the 10th day, only the germinal centres had been restored to their normal level, while the other sites showed a delay in recovery. The administration of Cyclophosphamide prior to DNCB sensitization resulted in a greater increase in pyroninophilic cells in the paracortical area of the regional lymph nodes than in the controls, between 7 to 13 days after sensitization. No increase was noted in the group that was given the drug after sensitization.Thus decrease in the lymph node component was accounted for by the B-cells which are susceptible to the effects of Cyclophosphamide, and the increase in pyroninophilic cells was attributed to this marked decrease in B-cells.

収録刊行物

• Shimane journal of medical science

  Shimane journal of medical science 4 (1), 23-30, 1980-06-01

  島根大学

キーワード

• Cyclophosphamide effects
• lymph nodes
• pyroninophilic cells

詳細情報

• CRID: 1050001338486095104
• NII論文ID: 110000012574
• NII書誌ID: AA00841586
• ISSN: 03865959
• Web Site: http://ir.lib.shimane-u.ac.jp/34520
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles