<Original Article>Ectopic Bone Formation by Biphasic Calcium Phosphate (BCP) Combined with Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)

  • Oda Shigeru
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.
  • Kinoshita Atsuhiro
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.
  • Higuchi Tatsuhiro
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.
  • Shizuya Toshio
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ishikawa Isao
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.

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We investigated ectopic bone formation by biphasic calcium phosphate (BCP) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in the rat dorsum. Under reduced pressure, rhBMP-2 was adsorbed onto BCP, which consisted of 80% β-tricalcium phosphate and 20% hydroxyapatite uniformly distributed in granules. Twenty Wistar rats were separated into 4 groups consisting of 5 animals each dosed with 2, 10, and 50 µg/700 µl of rhBMP-2 and a control group (BCP only). Pieces of the BCP-BMP complex or only BCP were implanted under the dorsal skin of the rats. Histological sections were examined three weeks later. New bone was formed in all rats given 50 µg doses, but not in the 2 µg and control groups. These results indicated that BCP combined with rhBMP-2 induced ectopic bone formation without additional carriers. Therefore, BCP granules alone can function as carriers for rhBMP-2 to induce bone formation.

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