Transdermal Delivery of Lidocaine in vitro by Alternating Current Transdermal Delivery of Lidocaine in vitro by Alternating Current

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著者

    • Kinoshita Tatsuki
    • Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical & Dental University
    • Shibaji Takao
    • Section of Orofacial Pain Management, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical & Dental University, Yushima Bunkyo-ku, Tokyo 113-8549, Japan
    • Umino Masahiro
    • Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical & Dental University

抄録

The purpose of this study was to investigatewhether lidocaine could be transported throughexcised rat skin in vitro using alternating current(AC). In addition, the relationships between factorssuch as voltage and frequency, and transportedlidocaine concentration were studied using the invitro model. A pair of platinum plate electrodes wasinstalled at opposite ends of two cylindrical glasscells in parallel to the full-thickness rat skin. Thedonor compartment was filled with 10 % lidocainehydrochloride, and the receptor compartmentwith Ringer solution. A sinusoidal wave wasapplied between the electrodes at 5 kinds of constantvoltages at 1 kHz and at 4 kinds of frequenciesat 20 volts. Our experimental system wassuccessfully used to quantify the concentration oftransported lidocaine induced by AC application.The applied sinusoidal waves evoked the transportof lidocaine through the rat skin at every voltageand frequency protocol. Our results suggest thatthe applied electric voltage and frequency affectthe movement of the lidocaine ions. We concludethat the transdermal delivery of lidocaine by ACiontophoresis has a possibility to use for localanesthesia and the pain management of the skin.

収録刊行物

  • Journal of Medical and Dental Sciences

    Journal of Medical and Dental Sciences 50(1), 71-77, 2003

    東京医科歯科大学

被引用文献:  7件中 1-7件 を表示

各種コード

  • NII論文ID(NAID)
    110000076020
  • NII書誌ID(NCID)
    AA12028964
  • 本文言語コード
    ENG
  • 資料種別
    departmental bulletin paper
  • ISSN
    1342-8810
  • データ提供元
    CJP引用  NII-ELS  IR  J-STAGE 
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