Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice

DOI 被引用文献2件
  • Choo-ryung J. Chung
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan Orthodontic Science, Tokyo Medical and Dental University, Tokyo, Japan
  • Tsuji Kunikazu
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
  • Nifuji Akira
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
  • Komori Toshihisa
    Department of Molecular Medicine, Osaka University Medical School, Osaka, Japan
  • Soma Kunimichi
    Orthodontic Science, Tokyo Medical and Dental University, Tokyo, Japan
  • Noda Masaki
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

この論文をさがす

抄録

Runx2/Cbfa1 is essential for osteoblast differentiation and bone formation. Runx2 null mice (Runx2-/-) completely lack mineralized tissue and die soon after birth, whereas Runx2 heterozygous knock-out mice (Runx2+/-) stay alive but show morphological defects in the skeletal system as observed in cleidocranial dysplasia (CCD) in humans. The aim of this study is to elucidate the role of Runx2 in adult mineralized tissue and also to reveal the distinct features of heterozygous deletion of Runx2 in response to tooth movement. Therefore, we examined the cranium, tooth and the periodontium in adult Runx2+/- using soft X-ray and micro-CT. In addition, tooth movement induced by mechanical loading was evaluated. In adult Runx2+/-, crown: root ratio of the first maxillary molar was significantly lower than that of wild type (WT). Irregularities in root morphology was also observed. The cranium was narrow with thin parietal bone compared to WT. Mechanical stressinduced tooth movement was similar between Runx2+/- and WT in terms of movement distance. However, while rotational movement between the first and third week was increased in WT, it was not altered in Runx2+/- mice. These data indicate that Runx2 plays a role in cranium and the tooth development in adulthood.

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ