EFFECTS OF CpG OLIGONUCLEOTIDES ON SCHISTOSOMA JAPONICUM INFECTION IN MICE

  • KUMAGAI TAKASHI
    Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences
  • EL-MALKY MOHAMED
    Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences
  • MURAYAMA HARUHIKO
    Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences
  • OHTA NOBUO
    Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences

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Abstract

Effects of CpG oligonucleotides on murine experimental Schistosoma japonicum infections were examined. Intramuscular injection of CpG oligonucleotides at the dose of 100 mg/kg biased host immune responses toward Th 1-dominance. When mice were treated with CpG oligonucleotides at the infection with S. japonicum, the egg production by female adult worms was significantly suppressed, suggesteing that some unknown stimulation related to Th 1 responses had inhibitory effects on sexual maturation of S. japonicum female worms. However, there was no difference in the number of recovered worms between CpG-treated and non-CpG treated groups. The mean size of hepatic circum egg eranulomas in CpG-treated mice was significantly smaller than that in non-CpG treated mice. Our present study suggests that CpG oligonucleotides might be applicable to morbidity control of schistosomiasis japonica as adjuvants in conjunction with classical vaccines.

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