両性イオン構造のL-リジンを側鎖にもつポリメタクリルアミドの調製とアルブミンとの相互作用  [in Japanese] Preparation of zwitterionic polymethacrylamide modified with L-lysine and interaction to Bovine Serum Albumin  [in Japanese]

Access this Article

Search this Article

Author(s)

    • 白石 浩平 SHIRAISHI Kohei
    • 近畿大学大学院工業技術研究科物質化学専攻 Program in Material Chemistry, Graduate School of Industrial Technology, Kinki University.
    • 光田 益士 KOHTA Masushi
    • 近畿大学大学院工業技術研究科物質化学専攻 Program in Material Chemistry, Graduate School of Industrial Technology, Kinki University.
    • 杉山 一男 SUGIYAMA Kazuo
    • 近畿大学大学院工業技術研究科物質化学専攻 Program in Material Chemistry, Graduate School of Industrial Technology, Kinki University.

Abstract

In order to develop a novel blood compatible material, zwitterionic polymer, poly(N-ε-methacrylamide-L-lysine) [poly(ε-LysMA)], was prepared as followed. (i)N-ε-methacrylamide-N-α-acethyl-L-lysine methylester was obtained from N-α-acethyl-L-lysine methylester and methacryloyl chloride. (ii) the monomer was radically polymerized with 2,2'-dimethylazobisisobutyrate in absolute ethanol at 60℃ for 20h. (iii) After deprotecting the resulting polymer with NaOHaq, zwitterionic poly(ε-LysMA) was neutrized, dialyzed with cellulose membrane against water and freeze-dried to give a white powder. The interaction between zwitterionic poly(ε-LysMA) and bovine serum albumin was also examined by fluorescence spectroscopy and using resonant mirror biosensor(LAsys).

Journal

  • Research reports of the Faculty of Engineering, Kinki University

    Research reports of the Faculty of Engineering, Kinki University (37), 7-12, 2003

    Kinki University

Codes

  • NII Article ID (NAID)
    110000976970
  • NII NACSIS-CAT ID (NCID)
    AN00063799
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • Journal Type
    大学紀要
  • ISSN
    0386491X
  • NDL Article ID
    6820758
  • NDL Source Classification
    ZM1(科学技術--科学技術一般)
  • NDL Call No.
    Z14-329
  • Data Source
    NDL  NII-ELS  IR 
Page Top