13. Bone Augmentation by BMP-Collagen composite in calvarial subperiosteum of matured rats. :

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  • Huang,Bingzhen
    Department of Oral Pathology, Okayama University, Dental School
  • Inoue,Masahisa
    Department of Oral Pathology, Okayama University, Dental School
  • Nakano,Keisuke
    Department of Oral Pathology, Okayama University, Dental School
  • Hoh,Chouhuku
    Department of Oral Pathology, Okayama University, Dental School
  • Nojima,Tetsundo
    Department of Oral Pathology, Okayama University, Dental School
  • Murata,Masaru
    Department of Oral Surgery 2, School of Dentistry, Health Science University of Hokkaido
  • Tsigono,Yoshiho
    Department of Oral Surgery, School of Medicine, Teikyo University
  • Nagai,Noriyuki
    Department of Oral Pathology, Okayama University, Dental School

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The composite of recombinant bone morphogenetic protein 2 (rhBMP-2) and type I atelocollagen fibers was implanted under the calvarial periosteum of wistar rats of 8 months old. Each composite was removed at 2, 4, 6, and 8 weeks after implantation, and evaluated histologically as an onlay bone graft substitute in a calvarial model. The results demonstrated that the composite of BMP and collagen was an effective material with osteoindtnctivity as an onlay bone graft substitute even in matured rats.

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