Immunohistochemical Study of Cytokeratin Patterns in Follicular and Plexiform Ameloblastoma :

• NAGATSUKA,Hitoshi

  Department of Oral Pathology, School of Dentistry, Okayama University

• SHIN,Hong-In

  Department of Oral Pathology, School of Dentistry, Kyungpook National University

• PARK,Hee-Kyung

  Department of Oral Pathology, School of Dentistry, Kyungpook National University

• ISHIWARI,Yuzo

  Department of Oral Pathology, School of Dentistry, Okayama University

• KURODA,Katsuhiro

  Department of Oral Pathology, School of Dentistry, Okayama University

• NOSAKA,Yukio

  Department of Oral Pathology, School of Dentistry, Okayama University

• SONG,Han

  Department of Oral Pathology, School of Dentistry, Okayama University

• QIN,Chun-Lin

  Department of Oral Pathology, School of Dentistry, Okayama University

• ZHANG,Shao-Quan

  Department of Oral Pathology, School of Dentistry, Okayama University

• NAKANO,Keisuke

  Department of Oral Pathology, School of Dentistry, Okayama University

• CHIGONO,Yoshiho

  First Department of Oral Surgery, Faculty of Medicine, Teikyo University

• TSUJIGIWA,Hidetsugu

  Department of Oral Pathology, School of Dentistry, Okayama University

• TAKAGI,Tohru

  Department of Biochemistry, Tokyo Medical and Dental University, Faculty of Dentistry, Yushima

• NAGAI,Noriyuki

  Department of Oral Pathology, School of Dentistry, Okayama University

抄録

The distribution of cytokeratin was investigated in follicular and plexiform ameloblastomas using immunohistochemical methods. The findings were compared with that of human fetal oral mucosa, developing tooth germ and adult gingiva. The following cytokeratin antibodies were used:CK-1,SE-K,NSE-K and 19-K. In the follicular ameloblastoma, the cytokeratin pattern of nest's structure was not comparable to that of the enamel organ at the bell stage. The peripheral columnar cells reacted positively for NES-K and 19-K and negatively for SE-K. The central stellate reticulum-like cells showed an immunoreactivity with all used markers of cytokeratins, as well as the outer enamel epithelium. In the plexiform ameloblastoma, the immunoreaction pattern was like that of the oral mucosal epithelium of the fetus. Both the central and peripheral cells demonstrated positive reactions with SE-K and 19-K but not with NSE-K. In the developing teeth, SE-K, NES-K and 1999-K were well demonstrated in the dental lamina, and each layer of the enamel organ. In the adult gingiva, contrary to the fetal oral mucosa, the basal cells did not show an immunoreactivity with 19-K except for Merkel cells. A clear difference in cytokeratin pattern was noted between ameloblastoma and tooth germs. Especially, the reactive pattern of NSE-K and 19-K showed differences between the peripheral columnar cells of ameloblastoma and the inner enamel epithelium. These findings support the concept that the columnar cells of follicular ameloblastomas have little resemblance to the pre-ameloblast like cells in the cytokeratin distribution.

収録刊行物

• Journal of hard tissue biology

  Journal of hard tissue biology 4 (2), 50-56,

  Japanese Society of Hard Tissue Research & Technology

キーワード

• Cytokeratin
• Immunohistochemistry
• Ameloblastoma
• Tooth Germ
• Fetal Oral Mucosa

詳細情報

• CRID: 1540009770417460608
• NII論文ID: 110001142330
• NII書誌ID: AA11074332
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/11134439
• 本文言語コード: en
• データソース種別:
  • NDL-Digital
  • CiNii Articles