Cell Kinetics and Bone Formation in Rat Condylar Fracture Model :

• SEKINE,Joji

  Second Department of Oral and Maxillofacial Surgery, Nagasaki University, School of Dentistry

• SANO,Kazuo

  Second Department of Oral and Maxillofacial Surgery, Nagasaki University, School of Dentistry

• INOKUCHI,Tsugio

  Second Department of Oral and Maxillofacial Surgery, Nagasaki University, School of Dentistry

抄録

The healing of the fracture as well as the cell proliferative activity of the condyle In the experimentally fractured rat condyles were evaluated by Yoshiki's method combined with bromodeoxyuridine (BrdU) immunohistochemistry. At fracture sites, osteoid matrix formation was observed at 1 and 2 weeks after the fracture in the ramal fragment and by the third week in the condylar fragment. The fracture gap was bridged at 4 weeks after its induction, when no osteoid was observed. Cell proliferation of the condyle was evaluated through the BrdU labeling index (LI) in the intermediate cell layer of the condyle at 1, 2, 3, 4 and 8 weeks after the fracture yielding a striking decrease in LIs up to 2 weeks, then a slight increase at 3 and 4 weeks after the fracture. Results showed that bone formation in the ramal fragment preceded that in the condylar fragment during the healing process of unilateral condylar fracture. Cell proliferative activity of the fractured condyle increased accompanied with bone formation in the condylar fragment.

収録刊行物

• Journal of hard tissue biology

  Journal of hard tissue biology 5 (3), 195-200,

  Japanese Society of Hard Tissue Research & Technology

キーワード

• Condylar fracture
• Cell proliferation
• Bromodeoxyuridine immunohistochemistry
• Osteoid
• Yoshiki's method

詳細情報

• CRID: 1543387470137991040
• NII論文ID: 110001142336
• NII書誌ID: AA11074332
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/11134469
• 本文言語コード: en
• データソース種別:
  • NDL-Digital
  • CiNii Articles