におい受容の分子メカニズム‐きゅう覚受容体が担う匂い識別の分子基盤‐

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  • 東原 和成
    東京大学大学院新領域創成科学研究科先端生命科学専攻

書誌事項

タイトル別名
  • How Do We Sense Scents?-Molecular Basis for Odorant Discrimination by Olfactory Receptors.
  • におい受容の分子メカニズム--嗅覚受容体が担う匂い識別の分子基盤
  • ニオイ ジュヨウ ノ ブンシ メカニズム キュウカク ジュヨウタイ ガ ニナウ ニオイ シキベツ ノ ブンシ キバン
  • -Molecular Basis for Odorant Discrimination by Olfactory Receptors
  • －嗅覚受容体が担う匂い識別の分子基盤－

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抄録

Olfactory receptors (ORs), which comprise the largest G protein-coupled receptor family, play a pivotal role in recognizing a variety of odorants in the vertebrate olfactory system. Recent successes in functional cloning and expression of ORs facilitated construction of ligand-activity matrices of ORs. Activation of a combinatorial receptor repertoire by an odorant determines an odor quality of the odorant, while activated ORs by an odorant mixture is not simply the sum of those for its components due to OR antagonism between odorants. Mixing odorants, thereby, often results in a novel perceptual quality that is not present in each component. The recent atomic-level structure for bovine rhodopsin has provided an opportunity to elucidate a molecular basis for odorant recognition by an OR and characterize the active site of an OR.

収録刊行物

  • 生物物理

    生物物理 44 (1), 26-31, 2004

    一般社団法人 日本生物物理学会

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