DNA二重鎖切断修復機構と減数分裂期組換え  [in Japanese] Mechanisms of DSB repair and their roles in meiosis  [in Japanese]

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Author(s)

Abstract

Genetic material suffers various spontaneous or environmental damages, among which DNA double-strand breaks (DSBs) are fatal to the cell since they bring to the loss of genetic information. Cells provide with two strategies to repair DSBs. One is through homologous recombination and the other through an end-to-end joining reaction. The former process is more accurate. <I>RAD52</I> group genes of budding yeast are involved in these DSB repair processes. They are classified into two subgroups: one is composed of <I>RAD51, 52, 54, 55 and 57</I> (<I>RAD51</I> subgroup), which are involved in homologous recombination, and the other <I>MRE11</I>, <I>RAD50</I> and <I>XRS2</I> (<I>MRE11</I> subgroup), which are involved in end-to-end joining.<BR>The DSB repair system is required for the proper segregation of homologous chromosomes in the reductional division of meiosis. Meiotic recombination is initiated with the formation of DSBs, the ends of which are processed and provided for homology search. Two subgroup genes work at two distinct steps: <I>MRE11</I> subgroup at DSB formation and <I>RAD51</I> subgroup at homology search, respectively. In addition, other meiosis specific proteins are also required for initiation and completion of meiotic recombination, some of which are components of synaptonemal complex.<BR>This review focuses on recent advances in the mechanism of DSB repair and its involvement in meiosis.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 38(4), 156-161, 1998-07

    The Biophysical Society of Japan General Incorporated Association

References:  26

Codes

  • NII Article ID (NAID)
    110001152923
  • NII NACSIS-CAT ID (NCID)
    AN00129693
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    05824052
  • NDL Article ID
    4527047
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z18-49
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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