Helicobacter pylori 除菌療法のラベプラゾールナトリウムと抗生剤2剤の2週間投与による消化性潰瘍の治癒効果

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  • Treatment of Peptic Ulcers in order to Eradicate Helicobacter Pylori by the Administration of Rabeprazole with Two Antibiotic Drugs for a Two week Period.
  • Ｈｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉ除菌療法のラベプラゾールナトリウムと抗生剤２剤の２週間投与による消化性潰ようの治癒効果

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Triple therapy (proton pump inhibitor + amoxicilln + clarithromycin) for one week is considered to be thecommon eradication therapy for Helicobacter pylori (H. pylori) infection.<BR>The H. pylori eradication rate has been reported to be 87. 5% after the administration of sodium rabeprazole, which is a proton pump inhibitor, along with two antibiotic drugs for one week [H. Miwa et al., Aliment. Pharmacol. Ther., 13, 741-746 (1999)] We performed a retrospective study to evaluate the treatment of 42 patients with H. pylori infection by the administration of sodium rabeprazole with two antibiotic drugs for a twoweek period. As a result, the H. pylori eradication rate was 93 % (39 of 42 patients). A successful healing of thepeptic ulcer with H. pylon was observed in all 39 patients. Side effects such as mild diarrhea appeared in onlyone patient. The triple therapy with sodium rabeprazole, amoxycillin, and clarithromycin for two weeks wastherefore found to be sufficiently effective in healing peptic ulcers with an H. pylori infection.

収録刊行物

  • 医療薬学

    医療薬学 29 (5), 599-602, 2003

    一般社団法人日本医療薬学会

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