塩酸オキシブチニン膀胱内注入療法における長期臨床使用成績調査　難治性尿失禁患者のQOLを改善した院内製剤

DOI 機関リポジトリ NDLデジタルコレクション 被引用文献1件 参考文献21件

書誌事項

タイトル別名
  • Evaluation of Clinical Outcome of Long-Term Intravesical Oxybutynin Therapy-Hospital Pharmaceutical Preparations Improved QOL for Patients with Refractory Urinary Incontinence-
  • 塩酸オキシブチニンぼうこう内注入療法における長期臨床使用成績調査―難治性尿失禁患者のＱＯＬを改善した院内製剤―
  • Hospital Pharmaceutical Preparations Improved QOL for Patients with Refractory Urinary Incontinence
  • 難治性尿失禁患者のQOLを改善した院内製剤

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抄録

The clinical outcome of long-term intravesical oxybutynin therapy to treat refractory urinary incontinence in 19 patients with a neuropathic bladder was evaluated by means of a questionnaire survey. Therapy consisted of self-instillation of a 10 mL solution containing 5 mg oxybutynin hydrochloride, which was prepared under sterile conditions in our hospital pharmacy, once (5 patients) or twice (14 patients) a day. Seventeen out of the 19 patients responded to the questionnaire and their mean therapy period was 7.3 years (2.5-10.3 years). Among them, only one became completely free of urinary incontinence. The patient response rate for effective or better regarding the efficacy of the drug was 76.5 % indicating that a large number of them were satisfied with the treatment. No patient experienced any serious local or systemic adverse effects.<BR>These results show that the quality of life of the patients was improved by long-term intravesical oxybutynin therapy. They also suggest that intravesical oxybutynin would be an effective and safe therapy for patients with a neuropathic bladder, who do not respond to oral medication or suffer from intolerable adverse effects due to it.

収録刊行物

  • 医療薬学

    医療薬学 30 (2), 83-87, 2004

    一般社団法人日本医療薬学会

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