院内製剤ジンクピリチオンローションの調整と物理学的特性  [in Japanese] Preparation of Zinc Pyrithion Lotion as a Hospiotal Preparation and Evaluation of its Physical Characteristics  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

In order to treat psoriasis, many kinds of drugs are administered systemically and topically. However, the topical admimistration of drugs is preferred to the systemic administration because the former can occasionally cause serious side effects. Zinc Pyrithione (ZPT), which is recognized as an active ingredient in a major anti-dandruff shampoo, was introduced as a new anti-psoriatic agent. In this study, ZPT lotions as a hospital preparation were prepared for topical administration. Hydroxypropylcellulose-H (HPC), sodium-polyacrylate (PANA) and carmellose sodium (CMC) were used as a suspending agent of 0.5% ZPT lotion. The following physical characteristics,the viscosity, the osmotic pressure, the sedimentation, the microscopic view and the dispersion were investigated in each ZPT lotion containing different suspended agents. The viscosity of the ZPT lotion with HPC and CMC Increased with the additive ratio of these suspended agents. On the other hand, the viscosity of the ZPT lotion with PANA increased logarithmically with its additive ratio. The low osmotic pressure of each lotion was expected to be less irritable in clinical application. When ZPT lotions were stored at room temperature for 14 days, the lotion with HPC or CMC showed free sedimentation and caking of the particles. In contrast, the lotion with PANA showed a growth of particles by a microscopic analysis and coagulated sedimentation by macroscopy. These phenomena may be due to the ionic intensity of the solution and the interaction between ZPT particles. The dispersion time of ZPT lotions with PANA was shorter than those with HPC or CMC. Based on our findings, 0.2% PANA was found to be preferable to HPC and CMC as the suspended agent in ZPT lotion.

Journal

  • 病院薬学 = Journal of the Nippon Hospital Pharmacists Association

    病院薬学 = Journal of the Nippon Hospital Pharmacists Association 25(6), 676-682, 1999-12-10

    日本病院薬剤師会

References:  9

  • <no title>

    上野賢一

    皮膚科学, 249-252, 1991

    Cited by (1)

  • <no title>

    PHILLIPS T. J.

    Hosp. Practice 31, 155-166, 1996

    Cited by (1)

  • <no title>

    日本病院薬剤師会編

    病院薬局製剤, 135-171, 1997

    Cited by (1)

  • <no title>

    瀬川富郎

    応用薬理 4, 883-890, 1970

    Cited by (1)

  • <no title>

    CRUTCHFIELD C. E.

    J. Geriatric Dermatol. 5, 21-24, 1997

    Cited by (1)

  • <no title>

    岩田政則

    薬剤学 42, 150-159, 1982

    Cited by (1)

  • <no title>

    中垣正幸編

    物性物理化学, 266-274, 1986

    Cited by (1)

  • <no title>

    宮嶋孝一郎編

    医薬品の開発 製剤の物理化学的性質 15, 314-321, 1991

    Cited by (1)

  • <no title>

    MARKS R.

    Br. J. Dermatol. 112, 415-422, 1985

    DOI  Cited by (2)

Codes

  • NII Article ID (NAID)
    110001166936
  • NII NACSIS-CAT ID (NCID)
    AN00002794
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    03899098
  • Data Source
    CJP  NII-ELS  NDL-Digital 
Page Top