健診で発見された特発性肺胞蛋白症の3例

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  • Three cases of idiopathic pulmonary alveolar proteinosis.

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Background: Idiopathic pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by deposition of proteineceous materials containing lipid in alveolar spaces. We report 3 cases of idiopathic PAP and describe cytological findings in bronchoalveolar lavage (BAL) fluid and histological findings of transbronchial lung biopsy specimens.<BR>Cases: The 3 patients-all men 48 to 50 years old were a symptomatic and pointed out due to abnormal shadows in chest radiography in a medical examination. Findings in chest computed tomography indicated PAP. BAL sediments all showed numerous, amorphous, granular materials within a finely granular background. Two also contained thick well-circumscribed globules.<BR>Conclusion: Microscopic examination of BAL sediment is useful for a definite clinicopathological diagnosis of PAP. Early diagnosis and treatment for PAP may lead to a good prognosis.

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