Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds

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Author(s)

    • Katakura Osamu
    • Oral Implantology and Regenerative Dental Medicine, Graduate school, Tokyo Medical and Dental University|Center of Excellence Program, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • Morimoto Nobuyuki
    • Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University|Center of Excellence Program, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • Iwasaki Yasuhiko
    • Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University|Center of Excellence Program, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • Akiyoshi Kazunari
    • Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University|Center of Excellence Program, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • Kasugai Shohei
    • Oral Implantology and Regenerative Dental Medicine, Graduate school, Tokyo Medical and Dental University|Center of Excellence Program, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University

Abstract

The ideal dressing material is bio-inert and keeps the wound site moist. It is equally important that no regenerative tissue is peeled off on the removal of the dressing. 2-Methacryloyloxyethyl phosphorylcholine (MPC) has a phospholipid polar group that mimics a biomembrane. We prepared poly [MPC-co-n-dodecyl methacrylate (DMA)] (PMD), using conventional radical polymerization with 2,2'-azobisisobutyronitrile as an initiator, and coated it on polyurethane (PU;Tecoflex® 60 Thermedics Inc.) membrane. Fullthickness surgical wounds were made on the dorsal skin of rats and wound healing was compared under the following three conditions: air-exposed control (no dressing), PU dressing, and PMD dressing. At 3, 4 and 7 days after the operation, the wound sizes of the PMD dressings were smaller than the non-dressed wound, and at 6 and 7 days after the operation, the wound sizes of PU dressing were smaller than that of the air-exposed group. But there were no significant difference between the PMD dressing group and PU dressing group. Histologically, scab formation was not observed on the PU or PMD-dressed wounds. However, in the air-exposed control, a scab was formed and reepithelialization of the wound site was prevented. Additionally, no damage was observed in the histological section of PMD dressed wound after the wound was cured. These results indicate that PMD dressing (PMD-coated PU membrane) has the potential to provide an inert environment for wound healing as well as PU.

The ideal dressing material is bio-inert andkeeps the wound site moist. It is equally importantthat no regenerative tissue is peeled off on theremoval of the dressing. 2-Methacryloyloxyethylphosphorylcholine (MPC) has a phospholipidpolar group that mimics a biomembrane. We preparedpoly [MPC-co-n-dodecyl methacrylate(DMA)] (PMD), using conventional radical polymerizationwith 2,2'-azobisisobutyronitrile as an initiator,and coated it on polyurethane (PU;Tecoflex<sup>®</sup> 60 Thermedics Inc.) membrane. Fullthicknesssurgical wounds were made on the dorsalskin of rats and wound healing was comparedunder the following three conditions: air-exposedcontrol (no dressing), PU dressing, and PMDdressing. At 3, 4 and 7 days after the operation, thewound sizes of the PMD dressings were smallerthan the non-dressed wound, and at 6 and 7 daysafter the operation, the wound sizes of PU dressingwere smaller than that of the air-exposed group.But there were no significant difference betweenthe PMD dressing group and PU dressing group.Histologically, scab formation was not observed onthe PU or PMD-dressed wounds. However, in theair-exposed control, a scab was formed and reepithelializationof the wound site was prevented.Additionally, no damage was observed in the histologicalsection of PMD dressed wound after thewound was cured. These results indicate thatPMD dressing (PMD-coated PU membrane) hasthe potential to provide an inert environment forwound healing as well as PU.

Journal

  • Journal of Medical and Dental Sciences

    Journal of Medical and Dental Sciences 52(2), 115-121, 2005

    Tokyo Medical and Dental University

Codes

  • NII Article ID (NAID)
    110001258608
  • NII NACSIS-CAT ID (NCID)
    AA12028964
  • Text Lang
    ENG
  • Article Type
    departmental bulletin paper
  • ISSN
    1342-8810
  • Data Source
    NII-ELS  IR  J-STAGE 
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