書誌事項
- タイトル別名
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- A case report of malignant mesothelioma. Cell pathology and cell kinetics.
- Cell pathology and cell kinetics
- 特に細胞病理学的特徴および細胞動態について
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A case of malignant mesothelioma of the peritoneum is presented with its cytology, histopathology, immunohistochemistry, electron microscopy and cell kinetics using bromodeoxyuridine (BrdU).<BR>A 50-year-old male was admitted to the Kochi medical school hospital because of ascites, and rt-cervical and ltinguinal tumors were also found. Abdominal CT scanning demonstrated thickened mesenterium and retroperitoneum. Cytology of peritoneal effusions and aspirates from these tumors revealed that numerous mesothelial cells with large papillary clusters contained multinucleated giant cells. A small numbers of intranuclear inclusions were also found. Histologically, biopsy specimens of these tumors were metastatic epithelial type of mesothelioma. Immunohistochemical staining with ABC method showed that the tumor cells were reacting positively for EMA, Vimentin and Keratin, however, negatively for CEA. Ultrastructural studies had demonstrated that the tumor cells had epithelial characteristics with numerous complex and elongated microvilli (MLDR=17-19). The percentage of BrdU positive mesothelioma cells was about 7% and it was higher than that of reactive mesothelial cells and macrophages obtained from other cases.<BR>It is sometimes difficult for identified the malignant epithelial mesothelioma cells in effusion cytology. However, it is important to find the nature of mesothelioma cells with special stains for hyaluronic acid, immunohistochemistry and electron microscopy. The findings of intranuclear inclusions and detection of cell kinetics using BrdU method may be useful for distinction between reactive mesothelial cells and malignant epithelial mesothelioma cells.
収録刊行物
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- 日本臨床細胞学会雑誌
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日本臨床細胞学会雑誌 28 (3), 444-449, 1989
公益社団法人 日本臨床細胞学会
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詳細情報 詳細情報について
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- CRID
- 1390282679670352896
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- NII論文ID
- 130003758266
- 110001281247
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- NII書誌ID
- AN00198721
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- ISSN
- 18827233
- 03871193
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可