Experimental Study of Biliary Excretion of an Antibiotics with Changes in Bile-Duct Pressure

1 Citations
  • NAKATA Koji
    Seocnd Division, Department of Surgery, Osaka City University Medical School
  • KINOSHITA Hiroaki
    Seocnd Division, Department of Surgery, Osaka City University Medical School
  • HIROHASHI Kazuhiro
    Seocnd Division, Department of Surgery, Osaka City University Medical School
  • TSUJI Yasutoshi
    Seocnd Division, Department of Surgery, Osaka City University Medical School
  • NAGATA Eiichi
    Seocnd Division, Department of Surgery, Osaka City University Medical School
  • KUBO Shoji
    Seocnd Division, Department of Surgery, Osaka City University Medical School
  • FUJIMOTO Mikio
    Department of Surgery, Fujiidera Municipal Hospital

Bibliographic Information

Other Title
  • 胆管内圧の変化による抗生剤の胆汁移行に関する実験的研究

Search this article

Abstract

The effect of bile-duct pressure on biliary excretion of the antibiotic flomoxef sodium (FMOX) was studied experimentally in healthy male beagles. The free end of a tube inserted in the common bile duct was fixed at a height of-10(A), 0(B), 10(C) or 20(D)cm from the anterior duct wall. An intravenous injection of 50mg/kg FMOX was given, and the drug concentration was assayed in the serum and bile during the next 5 hr. As the bile-duct pressure increased, total bile flow and total bile acid excretion decreased (A, 15.5ml and 607μmol ; B, 8.8 and 351 ; C, 7.7 and 201 ; D, 7.6 and 298). As the pressure increased, the biliary recovery and biliary Cmax decreased and the time of Cmax was delayed. (9.6%, 5770μg/ml, and 1〜1.5hr for A ; 5.4, 6037, and 1.5〜2 for B ; 4.6, 5170, and 2〜3 for C ; 3.1, 3257, and 2〜3 for D). There was no difference in the biological half-life, area under the curve, or total body clearance at different bile-duct pressures. However, the pharmacokinetic parameters of biliary excretion decreased and the lag time was prolonged with increased pressure. Apparently the bile-duct pressure affects the excretion of antibiotics into the bile.

Journal

Citations (1)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top