大腸癌における新しい癌抗原ｃｏａｇｕｌａｎｔ　ｃａｎｃｅｒ　ａｎｔｉｇｅｎ１の発現

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  • Expression of a Novel Cancer Antigen Coagulant Cancer Antigen 1 on Colorectal Cancers.

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The cancer specific antigen coagulant cancer antigen 1 (CCA-1) is a novel serine protease that has a strong potential to activate Factor X directly. The monoclonal antibody AI18, which recognizes CCA-1 and has a specific inhibitory effect on CCA-1 coagulant activity, was used for the immunohistological detection of CCA-1 on colorectal cancer tissues, and for comparison to CEA expression. CCA-1 expression on colorectal cancers was detected in 92% of the patients, while CEA was found in 98% of patients. Expression of CCA-1 on normal colorectal tissues was not observed, hence CEA was expressed in 72% of patients. Half the cases of colorectal adenoma and cancer'in-adenoma showed positive CCA-1 expression. CCA-1 expression was observed partially on squamous epithelial cells, gastric glands and bronchial mucoglands of normal adults and fetuses. CCA-1 is a novel cancer-specific antigen with well-characterized biological activity.

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