書誌事項
- タイトル別名
-
- Epidermal Growth Factor Receptor Overexpression in Human Esophageal Carcinoma and Its Relationship to the Proliferative Activity.
この論文をさがす
抄録
To determine the significance of epidermal growth factor receptor (EGFR) overexpression in human esophageal carcinoma, we immunohistochemically analyzed 60 tumors which were obtained from patients who underwent surgery. EGFR overexpression, located on the cancer cell membrane, was observed in 48% of these tumors. In a comparison with clinicopathological findings, significant correlations were observed between EGFR overexpression and lymph node metastasis, histologic stage or cumulative survival rate. On the other hand, to study the relationship between EGFR overexpression and the proliferative activities, we stained serial sections immunohistochemistrically by using the antiproliferating cell nuclear antigen (PCNA), and determined the PCNA labeling index (LI). There was no significant assosiation between EGFR overexpression and PCNA LI. Moreover, 34 tumors were transplanted into nude mice subcutaneously, and no significant association was found between EGFR overexpression and transplantability, growth type or doubling time of these transplanted tumors. These results suggest that the malignant potential of esophageal carcinoma with EGFR overexpression did not result from acceleration of the proliferative activity and EGFR seems to act as an enhancer of metastatic mechanism.
収録刊行物
-
- 日本消化器外科学会雑誌
-
日本消化器外科学会雑誌 29 (7), 1583-1590, 1996
一般社団法人 日本消化器外科学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204913830528
-
- NII論文ID
- 130004116999
- 110001320880
-
- NII書誌ID
- AN00192066
-
- ISSN
- 13489372
- 03869768
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
