Parathyroid hormone related protein およびG-CSF産生が認められた高カルシウム血症, 白血球増多症を呈した食道扁平上皮癌の1例

• 沖元 達也

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 八幡 浩

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 杉野 圭三

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 滝口 透

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 江本 健太郎

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 篠崎 勝則

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 丹治 英裕

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 片岡 健

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

• 嶋本 文雄

  Department of Pathology, Hiroshima University Hospital

• 浅原 利正

  Second Department of Surgery, Faculty of Medicine, Hiroshima University

書誌事項

タイトル別名

• A Case Report of Esophageal Carcinoma That Produced Parathyroid Hormone Related Protein (PTHrP) and G-CSF and Manifested Hypercalcemia and Leukocytosis

抄録

We report a case of esophageal carcinoma that manifested hypercalcemia and leukocytosis with the production of parathyroid hormone related protein (PTHrP) and G-CSF. A 72-year-old man had a type 2 tumor from Ut to Mt 6 cm in diameter. Blood cell count on admission showed leukocytosis (WBC 12, 100 mm³) but calcium was within normal limits (Ca⁺⁺7.4c 1.21mmol/l). Staging by imaging study was T3N2M0 Stage III. Subtotal esophagectomy was conducted on June 10, 1999. WBC count became normal after surgery. Hypercalcemia appeared on POD 69 accompanied by re-elevated WBC count. Parathyroid related protein in blood was 306 pmol/l and supernatant of cloned culture esophagus carcinoma was 272 pmol/l. Further immunohistochemical study showed positive staining of PTHrP and G-CSF in tumor cells. This is the first case, to our knowledge, in which simultaneous production of PTHrP and G-CSF was proved directly from esophageal squamous cell carcinoma cells.

収録刊行物

• 日本消化器外科学会雑誌

  日本消化器外科学会雑誌 35 (1), 35-39, 2002

  一般社団法人 日本消化器外科学会

キーワード

• Gastroenterology
• Surgery

詳細情報

• CRID: 1390001204913136256
• NII論文ID: 130004117442
• NII論文ID: 110001344146
• NII書誌ID: AN00192066
• DOI: 10.5833/jjgs.35.35
• ISSN: 13489372
• ISSN: 03869768
• Web Site: https://www.jstage.jst.go.jp/article/jjgs1969/35/1/35_1_35/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002106539
• データソース種別:
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  • Crossref
  • CiNii Articles
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