小野寺らのprognostic nutritional indexの再評価-特に高齢者胃・大腸癌に対する手術患者での検討-

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  • Re-evaluation of the Usefulness of the Prognostic Nutritional Index Reported by Onodera, Especially for the Elderly Patients Undergoing Gastrointestinal Surgery for the Gastric and Colon Cancer
  • Reported by Onodera, Especially for the Elderly Patients Undergoing Gastrointestinal Surgery for the Gastric and Colon Cancer
  • 特に高齢者胃・大腸癌に対する手術患者での検討

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Background: We evaluated the prognostic nutritional index (PNI), reported by Onodera, in patients un- dergoing gastrointestinal surgery for the gastric and colon cancer, and compared criteria for risk evaluation between younger and older patients. Methods: Subjects were 65 patients, 38 with gastric cancer, 18 with co-lon cancer, and 9 with rectal cancer, rated as Stage I or II. We evaluated the relationship between patient age and preoperative PNI, dividing by postoperative course into those with and without complications. We com- pared PNI was compared between groups. Patients were further assigned by age into an older group (≥75) or younger group. PNI was also compared between these groups. Results: The correlation between patient PNI and age was negative. The PNI in patients without complications was 42.9±5.7, while that in those with complications was 37.8±4.3, statistically significant (P=0.003). PNI in older patients was 39.8±5.0, while that in younger patients was 44.5±5.7, again statistically significant (P=0.001). In older and younger patients with complications, PNI was significantly lower in the older group at 35.5±4.8, versus 40.0±3.0 in the younger group (P=0.045). In the relationship between PNI and age relative to the postoperative course, a demarcation (PNI=46.2-0.071×Age) was observed between patients without and with complications. Conclusion: PNI decreased concomitantly with aging. In originally reported risk assessment criteria, most older patients were evaluated as risky or contraindicated for surgery. The demarcation line decreased concomitantly with age, in- dicating that preoperative risk assessment of older patients should take into account the decrease in PNI with aging.

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