A Case of Alpha-Feto-Protein (AFP) -Producing Metastatic Carcinoma of the Sigmoid Colon.
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- Kobayashi Masanori
- Department of Surgery, Cancer Institute Hospital
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- Kokudo Norihiro
- Department of Surgery, Cancer Institute Hospital
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- Seki Makoto
- Department of Surgery, Cancer Institute Hospital
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- Takahashi Takashi
- Department of Pathology, Cancer Institute Hospital
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- Yanagisawa Akio
- Department of Surgery of Saiseikai Kawaguchi General Hospital
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- Maekawa Katsujiro
- Department of Surgery of Saiseikai Kawaguchi General Hospital
Bibliographic Information
- Other Title
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- α‐fetoprotein産生S状結腸癌の1例
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Abstract
We report a case of alpha-feto-protein (AFP)-producing metastatic carcinoma of the sigmoid colon. A 65-year-old woman underwent sigmoidectomy for sigmoid colon cancer at another hospital. Eight months later abdominal CT showed a metastatic liver tumor in the left lobe. The serum AFP level was 1, 036.8 ng/ml at the time of diagnosis. Left bisegmentectomy and partial resection of the posterior segment was performed with curative intent. Twenty-six days after liver resection, a golf ball sized recurrent tumor was recognized in the subcutaneus tissue near the operation wound. Abdominal CT demonstrated tumor recurrence in the remnant liver. The patient died of hepatic failure ninety-four days after liver resection (1 year 4 month after the first operation). Histological findings of the primary lesion and liver tumor were moderatery differentiated adenocarcinoma including neoplastic cells with clear cytoplasm arranged in solid sheet or trabecular pattern (hepatoid differentiated areas). Immunohistochemical AFP staining showed AFP-positive cells. Both in the primary tumor and liver metastasis, AFP-positive cells were detected mainly in hepatoid differentiated areas. AFP-producing colorectal carcinomas tend to metastasize to the liver, and have a poor prognosis.
Journal
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- The Japanese Journal of Gastroenterological Surgery
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The Japanese Journal of Gastroenterological Surgery 32 (10), 2399-2403, 1999
The Japanese Society of Gastroenterological Surgery
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Details 詳細情報について
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- CRID
- 1390282679890621184
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- NII Article ID
- 130004343217
- 110001351350
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- NII Book ID
- AN00192066
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- ISSN
- 13489372
- 03869768
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed