酸化的ストレスによる８‐ＯＨ‐ｄＧの生成と修復酵素の応答

• 河井 一明

  産業医科大学職業性腫瘍学

• 葛西 宏

  産業医科大学職業性腫瘍学

書誌事項

タイトル別名

• Formation of 8-OH-dG by oxidative stress and response of repair enzymes
• 酸化的ストレスによる8-OH-dGの生成と修復酵素の応答
• サンカテキ ストレス ニ ヨル 8 OH dG ノ セイセイ ト シュウフク コウソ ノ オウトウ

抄録

Since the discovery of 8-OH-dG formation, various aspects of oxidative DNA damage have been studied. In the present decade, we have studied the chemistry of oxidative DNA damage, its mutagenic effects, and its repair mechanisms. We are also analyzing 8-OH-dG levels in human samples, such as leukocytes and urine, as a marker of oxidative DNA damage, to evaluate the oxidative stress of individuals. In the meantime, many groups have initiated studies of the biological significance of 8-OH-dG, and more than 2000 papers about 8-OH-dG have been published thus far. In this review, we will summarize our resent research progress on oxidative damage.

収録刊行物

• 環境変異原研究

  環境変異原研究 26 (2), 143-148, 2004

  日本環境変異原学会

キーワード

• 8-hydroxydeoxyguanosine
• 8-OH-dG
• DNA repair
• OGG1

詳細情報

• CRID: 1390282679397363968
• NII論文ID: 110001708217
• NII書誌ID: AN1006217X
• DOI: 10.3123/jems.26.143
• COI: 1:CAS:528:DC%2BD2cXhtVyit73L
• ISSN: 18807054
• ISSN: 09100865
• NDL書誌ID: 7116050
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7116050
• Web Site: https://search.jamas.or.jp/link/ui/2006114748
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可