Differential effects of systemic morphine on responses elicited by tooth pulp stimulation of nociceptive neurons in lateral and medial thalamic nuclei

• Nishikawa Yasuo

  Department of Physiology, Osaka Dental University

• Iwazumi Yukinori

  Department of Physiology, Osaka Dental University

• Hirota Tomio

  Department of Physiology, Osaka Dental University

• Endo Toshikazu

  Department of Physiology, Osaka Dental University

• Mukunoki Hideo

  Department of Physiology, Osaka Dental University

• Yoshida Yo

  Department of Physiology, Osaka Dental University

抄録

The effects of intravenous morphine on responses of feline thalamic nociceptive neurons receiving afferent input from the tooth pulp(TP)were investigated. Morphine suppressed responses to TP stimulation in both tooth pulp specific(TPS)and wide dynamic range(WDR)neurons with TP input recorded from the nucleus ventralis posteromedialis(VPM). However, there was scant morphine effect on responses to stimulation of trigeminothalamic tract(TTT)fibers in the trigeminal medial lemniscus. Furthermore, in nociceptive neurons with TP input recorded from nucleus centralis lateralis(CL)and parafascicularis(Pf)of the intralaminar nuclei, intravenous morphine suppressed responses both to stimulation of the mesencephalic reticular formation(MRF)as well as TP stimulation. The suppressive action of morphine on responses elicited by TP stimulation of VPM, CL and Pf neurons was antagonized by intravenous naloxone(1mg/kg). Results suggest that intravenous morphine suppresses synaptic transmission of nociceptive impulses in the intralaminar nuclei as well as in the lower brain stem but not in the VPM. (J Osaka Dent Univ 1998 Apr ; 32 : 17-26)

収録刊行物

• Journal of Osaka Dental University

  Journal of Osaka Dental University 32 (1), 17-26, 1998

  大阪歯科学会

キーワード

• Nucleus ventralis posteromedialis
• Nucleus centralis lateralis
• Nucleus parafascicularis
• Morphine
• Antinociception

詳細情報

• CRID: 1390001204963484928
• NII論文ID: 110001717528
• NII書誌ID: AA00704144
• DOI: 10.18905/jodu.32.1_17
• ISSN: 21896488
• ISSN: 04752058
• Web Site: https://search.jamas.or.jp/link/ui/1999045215
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可