3 4-nitroquinoline 1-oxide誘発ラット舌癌の発生過程におけるpRbの変化(第475回 大阪歯科学会例会)
書誌事項
- タイトル別名
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- Changes in pRb expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis
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We investigated immunohistochemical expression of pRb, cyclin D 1, and cdk 4 in rat tongue carcinoma induced by 4-nitroquinoline 1-oxide. pRb expression in carcinoma decreased compared with that in dysplastic lesions, while expression of cyclin D 1 and cdk 4 increased gradually during the course of carcinogenesis. Phosphorylation of pRb was analyzed by immunoblotting using the G 3-245 antibody, which recognizes both phosphorylated (pp 110^RB) and unphosphorylated pRb (p 110^RB). Although expression of pp 110^RB notably increased in the dysplastic membrane, it almost disappeared in carcinoma. p 110^RB was also expressed in control and dysplastic membranes, but not in carcinoma.In conclusion, there was a decrease of pRb and an increase of cdk 4 and cyclinD 1 in the premalignant stage. A decrease in the amount of pRb and an increase in its phosphorylation may prevent G 1 arrest and consequently accelerate proliferation of chemically injured cells.
収録刊行物
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- 歯科医学
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歯科医学 64 (1), 74-75, 2001
大阪歯科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204208986752
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- NII論文ID
- 110001724224
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- ISSN
- 2189647X
- 00306150
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可