統計家からの疑問：ｉｎ　ｖｉｔｒｏ試験のデータから定量的結論を導くのは邪道か？

• 吉村 功

  東京理科大学工学部

書誌事項

タイトル別名

• Why don't we use in vitro assays for quantitative risk assessment
• トウケイカ カラ ノ ギモン in vitro シケン ノ データ カラ テイリョウテキ ケツロン オ ミチビク ノ ワ ジャドウ カ

抄録

This paper discusses, from statistical viewpoint, about the methodology to examine whether substances have threshold on tumorgenecity or genotoxicity based on experiment data. When we try to discriminate models with threshold from those without threshold through in vivo experiment, the necessary sample size n will be too huge to be practical. In vitro assays seem to be more promising. Current methodologies utilized in in vitro assays, however, are not suitable for our purpose because they are involved in the determination of the positivity/negativity of test chemicals, while the methodologies we require are those for estimating dose-response relationships. Collaborative studies among toxicologists and statisticians are desirable to establish reasonable methodologies.

収録刊行物

• 環境変異原研究

  環境変異原研究 27 (2), 57-60, 2005

  日本環境変異原学会

キーワード

• dose-response relationship
• genotoxicity in vitro assay
• statistical analysis
• threshold

詳細情報

• CRID: 1390001204419645696
• NII論文ID: 130004476604
• NII論文ID: 110001789604
• NII書誌ID: AN1006217X
• DOI: 10.3123/jems.27.57
• COI: 1:CAS:528:DC%2BD2MXhtFWntLbN
• ISSN: 18807054
• ISSN: 09100865
• NDL書誌ID: 7440720
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7440720
• Web Site: https://search.jamas.or.jp/link/ui/2006015010
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可