ストレプトマイシンの血中濃度測定とファーマコキネティクス　　有効治療と副作用軽減のために

• 岩井 章洋

  国立療養所刀根山病院薬剤科

• 上野 裕和

  国立療養所刀根山病院薬剤科

• 松川 智洋

  国立療養所刀根山病院薬剤科

• 平井 乾壹

  国立療養所刀根山病院薬剤科

• 稲葉 収

  国立療養所刀根山病院薬剤科

• 網野 重雄

  国立療養所刀根山病院薬剤科

書誌事項

タイトル別名

• Pharmacokinetics and side effects of streptomycin.
• 有効治療と副作用軽減のために

抄録

Serum streptomycin (SM) concentrations in patients with pulmonary tuberculosis were determined by fluorescence polarization immuoassay (FPIA) method, and the relationships between the pharmacokinetics and the side effects of SM were investigated.<BR>SM clearance correlated with that of creatinine. However, some nonlinear pharmacokinetics were observed in patients who are over 60 years old and have less than 50ml/ min of Clcr, suggesting the relation to the appearance of the toxicity of SM. There was a tendency for the increase of oto-toxicity in patients with over 3 hrs of half-life (t_{1/ 2}) or over 35-50μg/ ml of maximum concentrations (C_max).<BR>It was suggested that the determination of serum SM concentration at 1 hr after intramuscular injection is important to avoid the appearance of the toxicity, since it correlated with C_max and SM clearance.

収録刊行物

• 病院薬学

  病院薬学 12 (6), 393-400, 1986

  一般社団法人 日本医療薬学会

キーワード

• streptomycin(SM)
• serum concentration
• fluorescence polarization immunoassay
• pharmacokinetics
• creatinine clearance
• oto-toxicity
• audibility

詳細情報

• CRID: 1390001204774589056
• NII論文ID: 110001798303
• NII書誌ID: AN00002794
• DOI: 10.5649/jjphcs1975.12.393
• ISSN: 21859477
• ISSN: 03899098
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10560631
• Web Site: https://search.jamas.or.jp/link/ui/1987182827
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可