テオフィリン製剤の体内動態と利尿作用 溶液と徐放錠の比較
書誌事項
- タイトル別名
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- Pharmacokinetics and diuretic effect of theophylline preparations. Comparison of oral solution and sustained-release tablets.
- Comparison of Oral Solution and Sustained-release Tablets
- 溶液と徐放錠の比較
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抄録
Plasma concentration, urinary excretion of theophylline and sodium excretion were investigated in 4 healthy adult volunteers after a single oral dose of 300mg theophylline in a solution form and in sustained-release tablets (Theodur). On the average plasma level curve for Theodur tablets, the peak level was reduced from 10μg/ml to 7μg/ml compared with that of an oral solution, but the prolonged effect for plasma level was observed and the absorption from dosage form was reliable.<BR>The renal clearance of theophylline increased initially after a single dose due to its urine flow rate dependence and after a single dose in a solution form the increase in urine flow rate was higher, thereby the initial increase in renal clearance became larger compared with those of sustained-release tablets.<BR>Furthermore, the urinary sodium excretion rate after a single dose increased as sigmoidshaped relationship with increasing the renal clearance of theophylline. And the natriuretic effect for oral solution was relatively potent, whereas that for sustained-release tablets appeared to be very weak.
収録刊行物
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- 病院薬学
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病院薬学 13 (6), 352-360, 1987
一般社団法人 日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679752883072
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- NII論文ID
- 110001798497
- 130004299035
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- NII書誌ID
- AN00002794
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- ISSN
- 21859477
- 03899098
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可