バルプロ酸ナトリウム坐剤の製剤学的検討および臨床応用
書誌事項
- タイトル別名
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- Pharmaceutical Examination of Sodium Valproate Rectal Suppository and Its Clinical Effect on Status Epilepticus and Neurosurgical Postoperative Epileptic Seizure
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The suppository for rectal administration of sodium valproate (VPA-Na) was prepared and its clinical effect was investigated in the epileptic patients to whom oral administration was difficult. We prepared two types of suppositories; type A included 600mg of VPA-Na, and type B included equivalent acetic acid in addition to 600mg of VPA-Na. VPA-Na contents in suppositories were determined using HPLC and plasma VPA concentration was determined by fluorescence polarization immunoassay. The content of VPA-Na in type A suppository gradually decreased to 78% by 4 months when stored in refrigerator, whereas it remained unchanged in type B. When these suppositories were rectally administered to six volunteers, type A showed the mean peak plasma VPA concentration (Cmax) of 16.6μg/ml and the area under the plasma concentration-time curve from O to 8h (AUC0-8) of 107.6μg・h/ml ,and type Bs howed Cmax of 47.7μg/ml and AUC 0-8 of 303.6μg・h/ml. The values of type B were significantly higher than those of type A. To three patients suffering from status epilepticus, type B suppositories were administered at doses of 600mg to 1,200mg every 8hr, and to four postoperative patients, suppositories were administered at a dose of 600mg for prophylaxis against neurosurgical postoperative epileptic seizure in addition to oral administration of 600mg of VPA-Na. Status epilepticus was well controlled, although small amount of diazepam were also injected. In four patients who underwent neurosurgical operation, the plasma concentration of VPA was maintained within the therapeutic range, and no epileptic seizure was observed. The present study suggests that undissociated VPA suppository is effective for some epileptic patients.
収録刊行物
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- 病院薬学
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病院薬学 19 (1), 8-17, 1993-02-20
日本病院薬剤師会
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詳細情報 詳細情報について
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- CRID
- 1541698620225904128
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- NII論文ID
- 110001798900
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- NII書誌ID
- AN00002794
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- 本文言語コード
- ja
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- データソース種別
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- NDL-Digital
- CiNii Articles