Effect of D-galactosamine on blood clearance of 99mTc-phytate in dogs.

• SHIBATA Hiroshi

• KOHNO Masahiro

抄録

The effect of D-galactosamine (GalN) on the blood clearance of ^99mTc-phytate (^99mTc-P) in dogs was examined, and the blood clearance test of ^99mTc-P was compared with the cases of the serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in dogs increased dose-dependantly after GalN administration, and the degree of increase in these parameters was much higher than the cases in rats. The disappearance rate of ^99mTc-p from blood in dogs decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of ^99mTc-P after GalN treatment in dogs may be influenced by the disorder in the hepatocytes. The blood clearance test of ^99mTc-P in dogs showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to the serum transaminase and bilirubin test.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 14 (4), 227-235, 1989

  一般社団法人　日本毒性学会

キーワード

• dog

詳細情報

• CRID: 1390282679877165056
• NII論文ID: 110001804760
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.14.227
• ISSN: 18803989
• ISSN: 03881350
• PubMed: 2625705
• Web Site: http://www.jstage.jst.go.jp/article/jts1976/14/4/14_4_227/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1993089233
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可