書誌事項
- タイトル別名
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- A SIX-MONTH INTRAVENOUS REPEATED DOSE TOXICITY STUDY OF TAZOB ACTAM/PIPERACILLIN AND TAZOBACTAM IN DOGS
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抄録
Tazobactam (TAZ) is a newly developed β-lactamase inhibitor. Tazobactam/Piperacillin (TAZ/PIPC) is a formulation consisting of TAZ and PIPC in a ratio of 1:4. A six-month intravenous repeated dose toxicity study of TAZ/PIPC and TAZ including a one-month recovery period were carried out using male and female dogs. The doses were 200, 400 and 800 mg/kg/day for TAZ/PIPC, and 40, 80 and 160 mg/kg/day for TAZ. The results were as follows. 1. No test article-related deaths occurred during the study period. No effects on clinical findings, body weight and food consumption were evident. 2. No test article-related changes were noted in hematological, serum biochemical and urinalysis evaluations, and ophthalmological and electrocardiographic examinations. 3. There were no test article-related changes in macroscopic findings or organ weight. 4. The histopathological examination revealed deposition of marked PAS-positive aggregates in liver cells of dogs given 400 mg/kg/day or more of TAZ/PIPC and 80 mg/kg/day or more of TAZ. Electron micrographs of hepatocytes revealed glycogen granules to be accumulated in the cytoplasm, and an increase of smooth endoplasmic reticulum. 5. After a one-month recovery period, the histopathological changes had generally disappeared, suggesting that they were reversible. 6. From the histopopathological changes of liver, the no-toxic dose levels for TAZ/PIPC and TAZ were 200 mg/kg/day and 40 mg/kg/day, respectively.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 19 (SupplementII), 177-197, 1994
一般社団法人 日本毒性学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679879067904
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- NII論文ID
- 110001805546
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可