Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors.

• KOBAYASHI Haruo

• SUZUKI Tadahiko

• KAMATA Ryo

• SAITO Shin-ya

• SATO Itaru

• TSUDA Shuji

• MATSUSAKA Naonori

抄録

Nicotine in tobacco, tetrahydrocannabinol (Δ⁹-THC) in marijuana and morphine in opium are well known as drugs associated with dependence or addiction. Endogenous active substances that mimic the effects of the natural drugs and their respective receptors have been found in the mammalian central nervous system (CNS). Such active substances and receptors include acetylcholine (ACh) and the nicotinic ACh receptor (nAChR) for nicotine, anandamide and CB1 for Δ⁹-THC, and endomorphins (1and2) and the μ(OP₃) opioid receptor for morphine, respectively. Considerable progress has been made in studies on neurotoxicity, in terms of the habituation, dependence and withdrawal phenomena associated with these drugs and with respect to correlations with endogenous active substances and their receptors. In this article we shall review recent findings related to the neurotoxicity of tobacco, marijuana and opium, and their toxic ingredients, nicotine, Δ⁹-THC and morphine in relation to their respective endogenous agents and receptors in the CNS.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 24 (1), 1-16, 1999

  一般社団法人　日本毒性学会

キーワード

• Tetrahydrocannabinol

詳細情報

• CRID: 1390282679879069056
• NII論文ID: 110001806362
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.24.1
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 4653470
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4653470
• Web Site: http://www.jstage.jst.go.jp/article/jts1976/24/1/24_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999190890
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可