(8)Effects of daily subcutaneous administration of reserpine on spermatogenesis for 2 and 4 weeks
書誌事項
- タイトル別名
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- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 8)EFFECTS OF DAILY SUBCUTANEOUS ADMINISTRATION OF RESERPINE ON SPERMATOGENESIS FOR 2 AND 4 WEEKS
- Effects of daily subcutaneous administration of reserpine on spermatogenesis for 2 and 4 weeks
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抄録
To obtain information on the validity and the limitations of 2-weeks repeated-dose toxicity studies to detect effects on the male genital organs of rats, reserpine was administered daily at 0.05 and 0.1 mg/kg by subcutaneous injection to Crj:CD(SD)IGS male rats for 2 and 4 weeks (2-weeks and 4-weeks studies). In the 2-weeks study, suppression of body weight gain was observed in the reserpine 0.1 mg/kg group. In the 4-weeks study, suppression of body weight gain and a decrease in prostate weight were observed in ne reserpine 0.1 mg/kg group. Slight to moderate retention of step 19 spermatids in the seminiferous tubules (stages IX-XI) was observed in a few animals of both the reserpine 0.05 and 0.1 mg/kg groups in both the 2- and 4-weeks studies. However, seminiferous tubule atrophy with degeneration of germ sells was observed sporadically not only in the reserpine groups but also in the control group, and this change might have been the cause of the spermatid retention. Therefore, we were unable to reach a clear conclusion with regard to whether it is possible to detect reserpine toxicity on spermatogenesis in rats after 2-weeks administration.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 25 (SpecialIssue), 87-94, 2000
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390001204902653056
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- NII論文ID
- 10007375064
- 110001806856
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 5546671
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- PubMed
- 11349459
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可