(24)Testicular toxicity of boric acid after 2-and4-week administration periods
書誌事項
- タイトル別名
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- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 24)TESTICULAR TOXICITY OF BORIC ACID AFTER 2-AND 4 -WEEK ADMINISTRATION PERIODS
- Testicular toxicity of boric acid after 2 and4 week administration periods
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抄録
To assess whether or not male reproductive toxicity can be evalutaed in a 2-week administration study, boric acid was administered daily by oral gavage to male Jcl:Wistar rats at dosage levels of 0, 300 and 500 mg/kg for 2 and 4 weeks, and the results obtained with the two different treatment schedules were compared. After a 2-week administration, decreased testis weights were observed in the 50O mg/kg group. Histopathologically, exfoliation of round spermatids, retention of step 19 spermatids and increased numbers of residual body-like structures in the seminiferous tubules and cell debris in the cranial epididymal ducts were observed in the 300 and 500 mg/kg groups. Distorted cytoplasmic lobes of step 19 spermatids, debris in the seminiferous tubules and focal atrophy of the seminiferous tubules with multinucleated giant cells formation and necrosis of spermatocytes were also observed in the 500 mg/kg group. After a 4-week administration, testis and epididymis weights were decreased in the 300 and 500 mg/kg groups. Histopathological changes in the 300 mg/kg group were similar to those found in the 300 and 500 mg/kg groups after a 2-week administration. Diffuse atrophy of the seminiferous tubules was additionally observed in the 500 mg/kg group. These results suggest that 2 weeks is a sufficient treatment period for the detection of the testicular toxicity caused by boric acid.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 25 (SpecialIssue), 233-239, 2000
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679879841024
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- NII論文ID
- 10007375047
- 110001806872
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 5547147
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- PubMed
- 11349449
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可