The effects of chlormadinone acetate (CMA), antiandrogen, on the pituitary, testis, prostate and adrenal gland of the dog with spontaneous benign prostatic hyperplasia.
-
- MURAKOSHI Masanori
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
- IKEDA Rie
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
-
- FUKUI Norio
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
書誌事項
- タイトル別名
-
- effects of chlormadinone acetate CMA antiandrogen on the pituitary testis prostate and adrenal gland of the dog with spontaneous benign prostatic hyperplasia
この論文をさがす
抄録
The effect of chlormadinone acetate (CMA), a synthetic steroidal antiandrogen, on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Male beagle dogs (5-8 years old) were divided into four experimental groups. Group 1 consisted of untreated controls. Groups 2 and 3 received CMA 0.03 and 0.1 mg/kg/day, p.o., respectively, for 6 months. In group 1, glandular hyperplasia of the prostate was clearly detected. The glandular epithelial cells showed uniformly intense nuclear staining for androgen receptor (AR). AR was also localized in the nuclei of the fibro-muscular stromal cells. In groups 2 and 3, CMA produced marked atrophy of the glandular epithelium. The interacinar fibro-muscular stroma was prominent. The nuclear staining for AR in both epithelial and stromal cells was remarkably decreased. In addition, a histopathological study showed that CMA medication for 6 months exerted no effect on the testes and adrenal glands or on immunoreactive positive cells to LH- and ACTH-antibody (pituitary LH- and ACTH-cells). Therefore, it is concluded that CMA (0.03 and 0.1 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes, adrenal glands or pituitary LH- and ACTH-cells.
収録刊行物
-
- The Journal of Toxicological Sciences
-
The Journal of Toxicological Sciences 26 (3), 119-127, 2001
一般社団法人 日本毒性学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679877056640
-
- NII論文ID
- 110001806913
-
- NII書誌ID
- AN00002808
-
- ISSN
- 18803989
- 03881350
-
- NDL書誌ID
- 5874865
-
- PubMed
- 11552295
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可