Nrf2-DEPENDENT GENE EXPRESSIONS : A MOLECULAR TOXICOLOGICAL ASPECT

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Author(s)

Abstract

Although NF-E2 related factor 2 (Nrf2) was found to be a transcriptional regulator that controls an expression of the β-globin gene, the notion is now widely accepted that this transfactor serves as a master regulator for the gene expression of a battery of proteins acting on anti-oxidative stress and detoxification of electrophiles. The function of Nrf2 that bears transcriptional activation depends solely on its nuclear localization, which is regulated by interaction with the cytosolic anchor protein Keap1 and its own turnover rate. In the present mini-review, we focus on the regulation of Nrf2 function and discuss the physiological and toxicological aspects of this transcriptional factor.<br>

Journal

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 29(2), 81-89, 2004-05-28

    The Japanese Society of Toxicology

References:  73

Cited by:  5

Codes

  • NII Article ID (NAID)
    110001812860
  • NII NACSIS-CAT ID (NCID)
    AN00002808
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    03881350
  • NDL Article ID
    6972740
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-1022
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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