経口蛋白同化ホルモンの神経系疾患患者における下肢筋力増強および筋肥大への効果

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  • Effect of Anabolic Steroid on Muscle Strength and Hypertrophy of Lower Legs in Patients with Nervous Diseases.
  • ケイコウ タンパク ドウカ ホルモン ノ シンケイケイ シッカン カンジャ ニ オケル カシ キンリョク ゾウキョウ オヨビ キン ヒダイ エ ノ コウカ

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We studied the effect of the anabolic steroid (AS) on the muscle strength and hypertrophy of the lower legs with voluntary movements. The subjects were 25 patients with nervous diseases, 16 males and 9 females, aged from 20 to 77 years (57.7±2.7 years), and the duration of the diseases were between 6 and 110 months (43.4±6.0 months). The patients were divided into two groups, control group (12 patients) with only voluntary exercise of the leg for 8 weeks, and AS group (13 patients) with voluntary leg exercise for 8 weeks plus oral anabolic steroid (oxymetron 20-40mg/day) for 4 weeks in the middle of the leg exercise. In addition to the traditional rehabilitation program, muscle exercise of the leg was performed in the sitting position using Cybex 6000. The patients were ordered to repeat knee extension/flexion isokinetic movements (60 and 180 degree/sec) with full power, 100-200 times/day with appropriate intervals, 5 days/week during 8 weeks of this study. Muscle strength were measured with Cybex 6000. The cross sectional area of the thigh were examined at 20cm below trochanter major by computer tomography. During 4 weeks of AS administration, significant increase of isokinetic and isometric muscle strength either on extension or flexion movements were observed. The increase of the cross sectional area of the exercised thigh was more prominent during 4 weeks of AS administration. As the adverse effects of AS, slight increase in AST, ALT and K was observed in 5 patients and returned within 1-2 weeks after cessation of AS. These results suggest anabolic steroid is significantly effective for muscle strength and hypertrophy.

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