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- Lee You-jin
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Gunduz Esra
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Tamamura Ryo
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Takagi Shin
- Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine and Dentistry, Okayama University
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- Kawahara Kenji
- Department of Oral and Maxillofacial Radiology, Graduate School of Medicine and Dentistry, Okayama University
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- Rui Kan
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Bingzhen Huang
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Gul San Ara Sathi
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Mahmoud Hashem Al Sheikh Ali
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Nagaoka Noriyuki
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Xiao Jing
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
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- Nagai Noriyuki
- Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University
この論文をさがす
抄録
The morphology and characteristics of melanosomes are important features for differentiating melanocyte-derived melanotic lesions such as benign and malignant melanoma. There are two types of melanosome; eumelanin and pheomelanin. In this study, we attempted to elucidate the characteristics of melanosomes in malignant melanomas (melanotic type and amelanotic type) by ultrastructural analysis. In the melanotic type malignant melanoma in situ, pleomorphic and ellipsoid abnormal melanosomes, so-called eumelanin melanosomes, were detected, together with an increase in alkali elution rate. In the melanotic type invasive malignant melanoma, irregular ellipsoid and spheroid melanosomes were found either as discrete bodies or compound melanosomes, with further increase in alkali elution. In the amelanotic type malignant melanoma in situ, there were no melanosomes in atypical melanocytes and keratinocytes. In the amelanotic type invasive malignant melanoma, a few round melanosomes with low density matrix, so-called pheomelanin melanosomes, distributed in the cytoplasm. Our findings suggest that abnormal melanosome morphology and characteristics are predictive differential markers for the melanotic type or amelanotic type of oral malignant melanomas.
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 13 (2), 87-90, 2004
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001204457592960
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- NII論文ID
- 110001876549
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可